Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Chris Johnson | TEN | at SD |
| 2 | Maurice Jones-Drew | JAX | at DAL |
| 3 | Arian Foster | HOU | at IND |
| 4 | Adrian Peterson | MIN | at NE |
| 5 | Frank Gore | SF | vs DEN |
| 6 | Steven Jackson | STL | vs CAR |
| 7 | Rashard Mendenhall | PIT | at NO |
| 8 | DeAngelo Williams | CAR | at STL |
| 9 | Felix Jones | DAL | vs NYG |
| 10 | Beanie Wells | ARI | vs TB |
| 11 | Darren McFadden | OAK | vs SEA |
| 12 | Jahvid Best | DET | vs WAS |
| 13 | Ryan Torain | WAS | at DET |
| 14 | Fred Jackson | BUF | at KC |
| 15 | Marshawn Lynch | SEA | at OAK |
| 16 | Pierre Thomas | NO | vs PIT |
| 17 | Jamaal Charles | KC | vs BUF |
| 18 | Cedric Benson | CIN | vs MIA |
| 19 | Thomas Jones | KC | vs BUF |
| 20 | Joseph Addai | IND | vs HOU |
| 21 | LaDanian Tomlinson | NYJ | vs GB |
| 22 | Ryan Mathews | SD | vs TEN |
| 23 | Jonathan Stewart | CAR | at STL |
| 24 | Brandon Jackson | GB | at NYJ |
| 25 | Ricky Williams | MIA | at CIN |
| 26 | Knowshon Moreno | DEN | at SF |
| 27 | Ronnie Brown | MIA | at CIN |
| 28 | BenJarvus Green-Ellis | NE | vs MIN |
| 29 | Brandon Jacobs | NYG | BYE |
| 30 | Marion Barber | DAL | vs NYG |
| 31 | Cadillac Williams | TB | at ARI |
| 32 | Michael Bush | OAK | vs SEA |
| 33 | Shonn Greene | NYJ | vs GB |
| 34 | Justin Forsett | SEA | at OAK |
| 35 | Javon Ringer | TEN | at SD |
