Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Peyton Manning | IND | vs HOU |
| 2 | Phillip Rivers | SD | vs TEN |
| 3 | Tom Brady | NE | vs MIN |
| 4 | Tony Romo | DAL | vs NYG |
| 5 | Ben Roethlisberger | PIT | at NO |
| 6 | Aaron Rodgers | GB | at NYJ |
| 7 | Matt Schaub | HOU | at IND |
| 8 | Drew Brees | NO | vs PIT |
| 9 | Donovan McNabb | WAS | at DET |
| 10 | Brett Favre | MIN | at NE |
| 11 | Kyle Orton | DEN | at SF |
| 12 | Carson Palmer | CIN | vs MIA |
| 13 | Vince Young | TEN | at SD |
| 14 | Sam Bradford | STL | vs CAR |
| 15 | Matt Cassel | KC | vs BUF |
| 16 | Chad Henne | MIA | at CIN |
| 17 | Mark Sanchez | NYJ | vs GB |
| 18 | Matthew Stafford | DET | vs WAS |
| 19 | Matt Hasselbeck | SEA | at OAK |
| 20 | Alex Smith | SF | vs DEN |
