Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Drew Brees | NO | vs CLE |
| 2 | Tom Brady | NE | at SD |
| 3 | Phillip Rivers | SD | vs NE |
| 4 | Aaron Rodgers | GB | vs MIN |
| 5 | Tony Romo | DAL | vs NYG |
| 6 | Eli Manning | NYG | at DAL |
| 7 | Ben Roethlisberger | PIT | at MIA |
| 8 | Kolb / Vick | PHI | at TEN |
| 9 | Brett Favre | MIN | at GB |
| 10 | Kyle Orton | DEN | vs OAK |
| 11 | Joe Flacco | BAL | vs BUF |
| 12 | Matt Ryan | ATL | vs CIN |
| 13 | Donovan McNabb | WAS | at CHI |
| 14 | Jay Cutler | CHI | vs WAS |
| 15 | Carson Palmer | CIN | at ATL |
| 16 | Vince Young | TEN | vs PHI |
| 17 | Sam Bradford | STL | at TB |
| 18 | Bruce Gradkowski | OAK | at DEN |
| 19 | David Garrard | JAX | at KC |
| 20 | Alex Smith | SF | at CAR |
