| Rank | Player | Team | Opponent |
| 1 | Drew Brees | NO | at TB |
| 2 | Phillip Rivers | SD | at STL |
| 3 | Peyton Manning | IND | at WAS |
| 4 | Aaron Rodgers | GB | vs MIA |
| 5 | Matt Schaub | HOU | vs KC |
| 6 | Eli Manning | NYG | vs DET |
| 7 | Donovan McNabb | WAS | vs IND |
| 8 | Tom Brady | NE | vs BAL |
| 9 | Matt Ryan | ATL | at PHI |
| 10 | Ben Roethlisberger | PIT | vs CLE |
| 11 | Joe Flacco | BAL | at NE |
| 12 | Jay Cutler | CHI | vs SEA |
| 13 | Tony Romo | DAL | at MIN |
| 14 | Vince Young | TEN | at JAX |
| 15 | Brett Favre | MIN | vs DAL |
| 16 | Kevin Kolb | PHI | vs ATL |
| 17 | Kyle Orton | DEN | vs NYJ |
| 18 | Sam Bradford | STL | vs SD |
| 19 | Shaun Hill | DET | at NYG |
| 20 | Mark Sanchez | NYJ | at DEN |
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