Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Chris Johnson | TEN | vs PHI |
| 2 | Maurice Jones-Drew | JAX | at KC |
| 3 | Ray Rice | BAL | vs BUF |
| 4 | Adrian Peterson | MIN | at GB |
| 5 | Steven Jackson | STL | at TB |
| 6 | Frank Gore | SF | at CAR |
| 7 | LeSean McCoy | PHI | at TEN |
| 8 | Rashard Mendenhall | PIT | at MIA |
| 9 | Pierre Thomas | NO | vs CLE |
| 10 | Jamaal Charles | KC | vs JAX |
| 11 | DeAngelo Williams | CAR | vs SF |
| 12 | Matt Forte | CHI | vs WAS |
| 13 | Ahmad Bradshaw | NYG | at DAL |
| 14 | Michael Turner | ATL | vs CIN |
| 15 | Peyton Hillis | CLE | at NO |
| 16 | Ryan Mathews | SD | vs NE |
| 17 | Felix Jones | DAL | vs NYG |
| 18 | Beanie Wells | ARI | at SEA |
| 19 | Cedric Benson | CIN | at ATL |
| 20 | Marshawn Lynch | SEA | vs ARI |
| 21 | Fred Jackson | BUF | at BAL |
| 22 | Ryan Torain | WAS | at CHI |
| 23 | Michael Bush | OAK | at DEN |
| 24 | Brandon Jackson | GB | vs MIN |
| 25 | Ricky Williams | MIA | vs PIT |
| 26 | Knowshon Moreno | DEN | vs OAK |
| 27 | BenJarvus Green-Ellis | NE | at SD |
| 28 | Cadillac Williams | TB | vs STL |
| 29 | Marion Barber | DAL | vs NYG |
| 30 | Ronnie Brown | MIA | vs PIT |
| 31 | Brandon Jacobs | NYG | at DAL |
| 32 | Darren McFadden | OAK | at DEN |
| 33 | Tim Hightower | ARI | at SEA |
| 34 | Jonathan Stewart | CAR | vs SF |
| 35 | Correll Buckhalter | DEN | vs OAK |
