Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Adrian Peterson | MIN | vs ARI |
| 2 | Arian Foster | HOU | vs SD |
| 3 | Ray Rice | BAL | vs MIA |
| 4 | LeSean McCoy | PHI | vs IND |
| 5 | Matt Forte | CHI | at BUF |
| 6 | Rashard Mendenhall | PIT | at CIN |
| 7 | Michael Turner | ATL | vs TB |
| 8 | Ahmad Bradshaw | NYG | at SEA |
| 9 | Darren McFadden | OAK | vs KC |
| 10 | Jamaal Charles | KC | at OAK |
| 11 | BenJarvus Green-Ellis | NE | at CLE |
| 12 | LaDanian Tomlinson | NYJ | at DET |
| 13 | Marshawn Lynch | SEA | vs NYG |
| 14 | Peyton Hillis | CLE | vs NE |
| 15 | Felix Jones | DAL | at GB |
| 16 | Joseph Addai | IND | at PHI |
| 17 | Beanie Wells | ARI | at MIN |
| 18 | Brandon Jackson | GB | vs DAL |
| 19 | Ryan Mathews | SD | at HOU |
| 20 | Cedric Benson | CIN | vs PIT |
| 21 | Fred Jackson | BUF | vs CHI |
| 22 | Jahvid Best | DET | vs NYJ |
| 23 | Jonathan Stewart | CAR | vs NO |
| 24 | Shonn Greene | NYJ | at DET |
| 25 | LeGarrette Blount | TB | at ATL |
| 26 | Pierre Thomas | NO | at CAR |
| 27 | Ronnie Brown | MIA | at BAL |
| 28 | Ricky Williams | MIA | at BAL |
| 29 | Marion Barber | DAL | at GB |
| 30 | Brandon Jacobs | NYG | at SEA |
| 31 | Michael Bush | OAK | vs KC |
| 32 | Justin Forsett | SEA | vs NYG |
| 33 | Darren Sproles | SD | at HOU |
| 34 | C.J. Spiller | BUF | vs CHI |
| 35 | Reggie Bush | NO | at CAR |
