Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Phillip Rivers | SD | at HOU |
| 2 | Drew Brees | NO | at CAR |
| 3 | Peyton Manning | IND | at PHI |
| 4 | Tom Brady | NE | at CLE |
| 5 | Aaron Rodgers | GB | vs DAL |
| 6 | Matt Schaub | HOU | vs SD |
| 7 | Michael Vick | PHI | vs IND |
| 8 | Eli Manning | NYG | at SEA |
| 9 | Brett Favre | MIN | vs ARI |
| 10 | Ben Roethlisberger | PIT | at CIN |
| 11 | Matt Ryan | ATL | vs TB |
| 12 | Mark Sanchez | NYJ | at DET |
| 13 | Joe Flacco | BAL | vs MIA |
| 14 | Jay Cutler | CHI | at BUF |
| 15 | Carson Palmer | CIN | vs PIT |
| 16 | Matt Cassel | KC | at OAK |
| 17 | Bruce Gradkowski | OAK | vs KC |
| 18 | Ryan Fitzpatrick | BUF | vs CHI |
| 17 | Matt Hasselbeck | SEA | vs NYG |
| 20 | Matthew Stafford | DET | vs NYJ |
