Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Peyton Manning | IND | vs SD |
| 2 | Phillip Rivers | SD | at IND |
| 3 | Drew Brees | NO | at DAL |
| 4 | Michael Vick | PHI | at CHI |
| 5 | Aaron Rodgers | GB | at ATL |
| 6 | Kyle Orton | DEN | vs STL |
| 7 | Tom Brady | NE | at DET |
| 8 | Eli Manning | NYG | vs JAX |
| 9 | Ben Roethlisberger | PIT | at BUF |
| 10 | Matt Ryan | ATL | vs GB |
| 11 | Joe Flacco | BAL | vs TB |
| 12 | Matt Schaub | HOU | vs TEN |
| 13 | Jon Kitna | DAL | vs NO |
| 14 | Matt Cassel | KC | at SEA |
| 15 | David Garrard | JAX | at NYG |
| 16 | Donovan McNabb | WAS | vs MIN |
| 17 | Ryan Fitzpatrick | BUF | vs PIT |
| 18 | Mark Sanchez | NYJ | vs CIN |
| 19 | Jay Cutler | CHI | vs PHI |
| 20 | Carson Palmer | CIN | at NYJ |
| 21 | Troy Smith | SF | at ARI |
| 22 | Sam Bradford | STL | at DEN |
| 23 | Brett Favre | MIN | at WAS |
| 24 | Matt Hasselbeck | SEA | vs KC |
| 25 | Shaun Hill | DET | vs NE |
