Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Peyton Manning | IND | at NE |
| 2 | Drew Brees | NO | vs SEA |
| 3 | Phillip Rivers | SD | vs DEN |
| 4 | Kyle Orton | DEN | at SD |
| 5 | Aaron Rodgers | GB | at MIN |
| 6 | Michael Vick | PHI | vs NYG |
| 7 | Tom Brady | NE | vs IND |
| 8 | Eli Manning | NYG | at PHI |
| 9 | Ben Roethlisberger | PIT | vs OAK |
| 10 | Ryan Fitzpatrick | BUF | at CIN |
| 11 | Matt Schaub | HOU | at NYJ |
| 12 | Jon Kitna | DAL | vs DET |
| 13 | Matt Ryan | ATL | at STL |
| 14 | Joe Flacco | BAL | at CAR |
| 15 | Carson Palmer | CIN | vs BUF |
| 16 | Jay Cutler | CHI | at MIA |
| 17 | Troy Smith | SF | vs TB |
| 18 | Mark Sanchez | NYJ | vs HOU |
| 19 | Vince Young | TEN | vs WAS |
| 20 | Donovan McNabb | WAS | at TEN |
| 21 | David Garrard | JAX | vs CLE |
| 22 | Sam Bradford | STL | vs ATL |
| 23 | Brett Favre | MIN | vs GB |
| 24 | Matt Cassel | KC | vs ARI |
| 25 | Matt Hasselbeck | SEA | at NO |
