Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Phillip Rivers | SD | vs SF |
| 2 | Michael Vick | PHI | at NYG |
| 3 | Peyton Manning | IND | vs JAX |
| 4 | Drew Brees | NO | at BAL |
| 5 | Kyle Orton | DEN | at OAK |
| 6 | Matt Ryan | ATL | at SEA |
| 7 | Jay Cutler | CHI | vs MIN |
| 8 | Tom Brady | NE | vs GB |
| 9 | Joe Flacco | BAL | vs NO |
| 10 | Eli Manning | NYG | vs PHI |
| 11 | Jon Kitna | DAL | vs WAS |
| 12 | Matt Schaub | HOU | at TEN |
| 13 | Ben Roethlisberger | PIT | vs NYJ |
| 14 | David Garrard | JAX | at IND |
| 15 | Matt Cassel | KC | at STL |
| 16 | Ryan Fitzpatrick | BUF | at MIA |
| 17 | Donovan McNabb | WAS | at DAL |
| 18 | Carson Palmer | CIN | vs CLE |
| 19 | Sam Bradford | STL | vs KC |
| 20 | Jason Campbell | OAK | vs DEN |
