Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Aaron Rodgers | GB | at DET |
| 2 | Michael Vick | PHI | at DAL |
| 3 | Phillip Rivers | SD | vs KC |
| 4 | Drew Brees | NO | vs STL |
| 5 | Peyton Manning | IND | at TEN |
| 6 | Kyle Orton | DEN | at ARI |
| 7 | Jay Cutler | CHI | vs NE |
| 8 | Joe Flacco | BAL | at HOU |
| 9 | Tom Brady | NE | at CHI |
| 10 | Matt Ryan | ATL | at CAR |
| 11 | Ben Roethlisberger | PIT | vs CIN |
| 12 | Eli Manning | NYG | at MIN |
| 13 | Jon Kitna | DAL | vs PHI |
| 14 | Ryan Fitzpatrick | BUF | vs CLE |
| 15 | Matt Schaub | HOU | vs BAL |
| 16 | Matt Cassel | KC | at SD |
| 17 | David Garrard | JAX | vs OAK |
| 18 | Donovan McNabb | WAS | vs TB |
| 19 | Mark Sanchez | NYJ | vs MIA |
| 20 | Derek Anderson | ARI | vs DEN |
