Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Arian Foster | HOU | at JAX |
| 2 | Frank Gore | SF | vs STL |
| 3 | Maurice Jones-Drew | JAX | vs HOU |
| 4 | Chris Johnson | TEN | at MIA |
| 5 | Adrian Peterson | MIN | at CHI |
| 6 | Ray Rice | BAL | at ATL |
| 7 | LeSean McCoy | PHI | at WAS |
| 8 | Steven Jackson | STL | at SF |
| 9 | Rashard Mendenhall | PIT | vs NE |
| 10 | Matt Forte | CHI | vs MIN |
| 11 | Jamaal Charles | KC | at DEN |
| 12 | Michael Turner | ATL | vs BAL |
| 13 | Ahmad Bradshaw | NYG | vs DAL |
| 14 | LaDanian Tomlinson | NYJ | at CLE |
| 15 | Ryan Torain | WAS | vs PHI |
| 16 | Jahvid Best | DET | at BUF |
| 17 | Cedric Benson | CIN | at IND |
| 18 | Fred Jackson | BUF | vs DET |
| 19 | Beanie Wells | ARI | vs SEA |
| 20 | DeAngelo Williams | CAR | at TB |
| 21 | Felix Jones | DAL | at NYG |
| 22 | Marshawn Lynch | SEA | at ARI |
| 23 | Peyton Hillis | CLE | vs NYJ |
| 24 | BenJarvus Green-Ellis | NE | at PIT |
| 25 | Knowshon Moreno | DEN | vs KC |
| 26 | Ronnie Brown | MIA | vs TEN |
| 27 | Shonn Greene | NYJ | at CLE |
| 28 | LeGarrette Blount | TB | vs CAR |
| 29 | C.J. Spiller | BUF | vs DET |
| 30 | Danny Woodhead | NE | at PIT |
| 31 | Thomas Jones | KC | at DEN |
| 32 | Joseph Addai | IND | vs CIN |
| 33 | Brandon Jacobs | NYG | vs DAL |
| 34 | Tim Hightower | ARI | vs SEA |
| 35 | Donald Brown | IND | vs CIN |
