Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Peyton Manning | IND | vs CIN |
| 2 | Matt Schaub | HOU | at JAX |
| 3 | Michael Vick | PHI | at WAS |
| 4 | Ben Roethlisberger | PIT | vs NE |
| 5 | Eli Manning | NYG | vs DAL |
| 6 | Kyle Orton | DEN | vs KC |
| 7 | Ryan Fitzpatrick | BUF | vs DET |
| 8 | Tom Brady | NE | at PIT |
| 9 | Mark Sanchez | NYJ | at CLE |
| 10 | Vince Young | TEN | at MIA |
| 11 | Donovan McNabb | WAS | vs PHI |
| 12 | Carson Palmer | CIN | at IND |
| 13 | Jay Cutler | CHI | vs MIN |
| 14 | Joe Flacco | BAL | at ATL |
| 15 | Matt Ryan | ATL | vs BAL |
| 16 | Brett Favre | MIN | at CHI |
| 17 | Matt Cassel | KC | at DEN |
| 18 | Jon Kitna | DAL | at NYG |
| 19 | Sam Bradford | STL | at SF |
| 20 | Alex Smith | SF | vs STL |
