Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Chris Johnson | TEN | at HOU |
| 2 | Arian Foster | HOU | vs TEN |
| 3 | Adrian Peterson | MIN | at WAS |
| 4 | Maurice Jones-Drew | JAX | at NYG |
| 5 | Frank Gore | SF | at ARI |
| 6 | Ray Rice | BAL | vs TB |
| 7 | LeSean McCoy | PHI | at CHI |
| 8 | Peyton Hillis | CLE | vs CAR |
| 9 | Steven Jackson | STL | at DEN |
| 10 | Jamaal Charles | KC | at SEA |
| 11 | Rashard Mendenhall | PIT | at BUF |
| 12 | Ahmad Bradshaw | NYG | vs JAX |
| 13 | Michael Turner | ATL | vs GB |
| 14 | Darren McFadden | OAK | vs MIA |
| 15 | Felix Jones | DAL | vs NO |
| 16 | Matt Forte | CHI | vs PHI |
| 17 | LaDanian Tomlinson | NYJ | vs CIN |
| 18 | Cedric Benson | CIN | at NYJ |
| 19 | Jahvid Best | DET | vs NE |
| 20 | Brandon Jackson | GB | at ATL |
| 21 | Fred Jackson | BUF | vs PIT |
| 22 | LeGarrette Blount | TB | at BAL |
| 23 | Keiland Williams | WAS | vs MIN |
| 24 | Marshawn Lynch | SEA | vs KC |
| 25 | Knowshon Moreno | DEN | vs STL |
| 26 | Danny Woodhead | NE | at DET |
| 27 | BenJarvus Green-Ellis | NE | at DET |
| 28 | Ryan Mathews | SD | at IND |
| 29 | Donald Brown | IND | vs SD |
| 30 | Ricky Williams | MIA | at OAK |
| 31 | Reggie Bush | NO | at DAL |
| 32 | Tim Hightower | ARI | vs SF |
| 33 | Beanie Wells | ARI | vs SF |
| 34 | Brandon Jacobs | NYG | vs JAX |
| 35 | Shonn Greene | NYJ | vs CIN |
| 36 | Jason Snelling | ATL | vs GB |
| 37 | Thomas Jones | KC | at SEA |
| 38 | Ronnie Brown | MIA | at OAK |
| 39 | Michael Bush | OAK | vs MIA |
| 40 | Javon Ringer | TEN | at HOU |
