Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Frank Gore | SF | vs TB |
| 2 | Maurice Jones-Drew | JAX | vs CLE |
| 3 | Chris Johnson | TEN | vs WAS |
| 4 | Adrian Peterson | MIN | vs GB |
| 5 | Arian Foster | HOU | at NYJ |
| 6 | Ray Rice | BAL | at CAR |
| 7 | LeSean McCoy | PHI | vs NYG |
| 8 | Steven Jackson | STL | vs ATL |
| 9 | Michael Turner | ATL | at STL |
| 10 | Rashard Mendenhall | PIT | vs OAK |
| 11 | Jamaal Charles | KC | vs ARI |
| 12 | Ahmad Bradshaw | NYG | at PHI |
| 13 | Felix Jones | DAL | vs DET |
| 14 | Darren McFadden | OAK | at PIT |
| 15 | Cedric Benson | CIN | vs BUF |
| 16 | Peyton Hillis | CLE | at JAX |
| 17 | Matt Forte | CHI | at MIA |
| 18 | LaDanian Tomlinson | NYJ | vs HOU |
| 19 | Beanie Wells | ARI | at KC |
| 20 | Ryan Torain | WAS | at TEN |
| 21 | Jahvid Best | DET | at DAL |
| 22 | Brandon Jackson | GB | at MIN |
| 23 | Fred Jackson | BUF | at CIN |
| 24 | Danny Woodhead | NE | vs IND |
| 25 | LeGarrette Blount | TB | at SF |
| 26 | BenJarvus Green-Ellis | NE | vs IND |
| 27 | Marshawn Lynch | SEA | at NO |
| 28 | Knowshon Moreno | DEN | at SD |
| 29 | Ryan Mathews | SD | vs DEN |
| 30 | Pierre Thomas | NO | vs SEA |
| 31 | Reggie Bush | NO | vs SEA |
| 32 | Jason Snelling | ATL | at STL |
| 33 | Ricky Williams | MIA | vs CHI |
| 34 | Tim Hightower | ARI | at KC |
| 35 | Donald Brown | IND | at NE |
| 36 | Thomas Jones | KC | vs ARI |
| 37 | Brandon Jacobs | NYG | at PHI |
| 38 | Shonn Greene | NYJ | vs HOU |
| 39 | Javon Ringer | TEN | vs WAS |
| 40 | Michael Bush | OAK | at PIT |
