Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Chris Johnson | TEN | vs HOU |
| 2 | Arian Foster | HOU | at TEN |
| 3 | LeSean McCoy | PHI | at NYG |
| 4 | Maurice Jones-Drew | JAX | at IND |
| 5 | Peyton Hillis | CLE | at CIN |
| 6 | Adrian Peterson | MIN | at CHI |
| 7 | Steven Jackson | STL | vs KC |
| 8 | Michael Turner | ATL | at SEA |
| 9 | Jamaal Charles | KC | at STL |
| 10 | Ray Rice | BAL | vs NO |
| 11 | Knowshon Moreno | DEN | at OAK |
| 12 | Ahmad Bradshaw | NYG | vs PHI |
| 13 | Felix Jones | DAL | vs WAS |
| 14 | Rashard Mendenhall | PIT | vs NYJ |
| 15 | Darren McFadden | OAK | vs DEN |
| 16 | Matt Forte | CHI | vs MIN |
| 17 | Fred Jackson | BUF | at MIA |
| 18 | LeGarrette Blount | TB | vs DET |
| 19 | Tim Hightower | ARI | at CAR |
| 20 | BenJarvus Green-Ellis | NE | vs GB |
| 21 | Marshawn Lynch | SEA | vs ATL |
| 22 | Brian Westbrook | SF | at SD |
| 23 | Cedric Benson | CIN | vs CLE |
| 24 | Jahvid Best | DET | at TB |
| 25 | Brandon Jacobs | NYG | vs PHI |
| 26 | Mike Tolbert | SD | vs SF |
| 27 | Keiland Williams | WAS | at DAL |
| 28 | Jonathan Stewart | CAR | vs ARI |
| 29 | LaDanian Tomlinson | NYJ | at PIT |
| 30 | Brandon Jackson | GB | at NE |
| 31 | Ronnie Brown | MIA | vs BUF |
| 32 | Mike Goodson | CAR | vs ARI |
| 33 | Ricky Williams | MIA | vs BUF |
| 34 | Shonn Greene | NYJ | at PIT |
| 35 | Danny Woodhead | NE | vs GB |
