Other Rankings: QB RB WR TE
| Rank | Player | Team | Opponent |
| 1 | Chris Johnson | TEN | vs IND |
| 2 | Peyton Hillis | CLE | at BUF |
| 3 | Adrian Peterson | MIN | vs NYG |
| 4 | Arian Foster | HOU | vs BAL |
| 5 | LeSean McCoy | PHI | at DAL |
| 6 | Maurice Jones-Drew | JAX | vs OAK |
| 7 | Steven Jackson | STL | at NO |
| 8 | Jamaal Charles | KC | at SD |
| 9 | Michael Turner | ATL | at CAR |
| 10 | Ray Rice | BAL | at HOU |
| 11 | Rashard Mendenhall | PIT | vs CIN |
| 12 | Knowshon Moreno | DEN | at ARI |
| 13 | Ahmad Bradshaw | NYG | at MIN |
| 14 | Matt Forte | CHI | vs NE |
| 15 | Felix Jones | DAL | vs PHI |
| 16 | Fred Jackson | BUF | vs CLE |
| 17 | LaDanian Tomlinson | NYJ | vs MIA |
| 18 | LeGarrette Blount | TB | at WAS |
| 19 | Tim Hightower | ARI | vs DEN |
| 20 | Darren McFadden | OAK | at JAX |
| 21 | BenJarvus Green-Ellis | NE | at CHI |
| 22 | Marshawn Lynch | SEA | at SF |
| 23 | Brian Westbrook | SF | vs SEA |
| 24 | Cedric Benson | CIN | at PIT |
| 25 | Brandon Jackson | GB | at DET |
| 26 | Mike Tolbert | SD | vs KC |
| 27 | Brandon Jacobs | NYG | at MIN |
| 28 | Michael Bush | OAK | at JAX |
| 29 | Jahvid Best | DET | vs GB |
| 30 | Beanie Wells | ARI | vs DEN |
| 31 | Tyrell Sutton | CAR | vs ATL |
| 32 | Keiland Williams | WAS | vs TB |
| 33 | Shonn Greene | NYJ | vs MIA |
| 34 | Ricky Williams | MIA | at NYJ |
| 35 | Ronnie Brown | MIA | at NYJ |
